| skos:altLabel | - :U.S. Route 221 in South Carolina#South Carolina Highway 110
- U.S. Highway 221
- U.S. Route 221
- U.S. Route 221
- US 221
- US 221
- US-221
- U.S. Route 221 in South Carolina#Troy alternate route
- U.S. Route 221 in South Carolina#South Carolina Highway 110
- U.S. Route 221 in South Carolina#South Carolina Highway 104
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